ANTI-CANCER PHYTOCHEMICAL-BASED STUDIES
Updated: 12 January 2024
The global affliction of cancer is concerning as it is one of the leading causes of increased mortality rates world-wide. Most currently available anti-cancer drugs are associated with many challenges, such as drug resistance or clinical relapse. Consequently, these challenges have motivated extensive investigations of alternative treatments displaying improved anti-cancer and pharmacokinetic properties.
Phytochemicals (biologically active plant derived compounds) have established their anti-cancer effects in several cancer cell lines and animal models; and have also demonstrated their potential as chemo-preventative compounds.
Below is a list of resources relating to anti-cancer studies involving phytochemicals. Please note, the information on this website is provided for general information only.
Ahmed K, Zaidi SF, Cui Z, Zhou D, Saeed SA, Inadera H (2019). Potential pro-apoptotic phytochemical agents for the treatment and prevention of colorectal cancer (Review). Oncology Lett 18(1): 487-498. https://doi.org/10.3892/ol.2019.10349
Anantharaju PG, Gowda PC, Vimalambike MG et al. (2016). An overview on the role of dietary phenolics for the treatment of cancers. Nutr J 15:99.
Ashraf MA (2020). Phytochemicals as potential anticancer drugs: Time to ponder nature’s bounty. Biomed Res Int. 2020:8602879. https://doi.org/10.1155/2020/8602879
Ballout F, Monzer A, Fatfat M, Ouweini H El, Jaffa MA, Abdel-Samad R, Darwiche N, Abou-Kheir W, Gali-Muhtasib H (2020). Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem/progenitor cells. Oncotarget. 11: 2959-2972. https://doi.org/10.18632/oncotarget.27426
Briguglio G, Costa C, Pollicino M, Giambò F, Catania S, Fenga C (2020). Polyphenols in cancer prevention: New insights (Review). Int J Funct Nutr 1:9. https://doi.org/10.3892/ijfn.2020.9
Changxing L, Galani S, Hassan FU, Rashid Z, Naveed M, et al. (2020). Biotechnological approaches to the production of plant-derived promising anticancer agents: An update and overview. Biomed Pharmacother 132:110918.
Choudhari AS, Mandave PC, Deshpande M, Ranjekar P, Prakash O (2020). Phytochemicals in cancer treatment: from preclinical studies to clinical practice. Front Pharmacol 10:1614.
Dave A, Parande F, Park EJ, Pezzuto JM (2020). Phytochemicals and cancer chemoprevention. JCMT 6:46. http://dx.doi.org/10.20517/2394-4722.2020.106
George BP, Chandran R, Abrahamse H (2021). Role of phytochemicals in cancer chemoprevention: Insights. Antioxidants (Basel)10(9):1455. https://doi.org/10.3390/antiox10091455
González-Vallinas M, González-Castejón M, Rodríguez-Casado A, Ramírez de Molin A (2013). Dietary phytochemicals in cancer prevention and therapy: a complementary approach with promising perspectives. Nutr Rev 71(9):585–599. https://doi.org/10.1111/nure.12051
Hano C, Tungmunnithum D (2020). Plant Polyphenols, more than just simple natural antioxidants: oxidative stress, aging and age-related diseases. Med (Basel, Switzerland) 7(5):26.
Israel BB, Tilghman SL, Parker-Lemieux K, Payton-Stewart F (2018). Phytochemicals: Current strategies for treating breast cancer. Oncol Lett. 15(5):7471-7478. doi: 10.3892/ol.2018.8304. Epub 2018 Mar 20. PMID: 29755596; PMCID: PMC5943681.
Kapinova A, Kubatka P, Golubnitschaja O, et al. (2018). Dietary phytochemicals in breast cancer research: anticancer effects and potential utility for effective chemoprevention. Environ Health Prev Med 23:36. https://doi.org/10.1186/s12199-018-0724-1
Kocyigit A, Guler EM, Dikilitas M (2018). Role of antioxidant phytochemicals in prevention, formation and treatment of cancer. InTech. doi: 10.5772/intechopen.72217
Kotecha R, Takami A, Espinoza J (2016). Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence. Oncotarget 7(32):52517-52529. https://doi.org/10.18632/oncotarget.9593
Kumar N, Gupta S, Yadav TC, Pruthi V, Varadwaj PK, Goel N (2019). Extrapolation of phenolic compounds as multi-target agents against cancer and inflammation. J Biomol Struct Dyn 37(9):2355-2369.
Masuelli L, Benvenuto M, Fantini M, Marzocchella L, Sacchetti P, Di Stefano E, Tresoldi I, Izzi V, Bernardini R, Palumbo C, et al. (2013). Curcumin induces apoptosis in breast cancer cell lines and delays the growth of mammary tumors in neu transgenic mice. J Biol Regul Homeost Agents. 27:105–119. https://pubmed.ncbi.nlm.nih.gov/23489691/
Mazurakova A, Koklesova L, Samec M et al. (2022). Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care. EPMA J 13:315–334. https://doi.org/10.1007/s13167-022-00277-2
Ranjan A, Ramachandran S, Gupta N, Kaushik I, Wright S, Srivastava S, Das H, Srivastava S, Prasad S, Srivastava SK (2019). Role of phytochemicals in cancer prevention. Int J Mol Sci 20(20):4981. https://doi.org/10.3390/ijms20204981
Rizeq B, Gupta I, Ilesanmi J, AlSafran M, Rahman MDM, Ouhtit A (2020). The power of phytochemicals combination in cancer chemoprevention. J Cancer 11(15):4521-4533. https://doi.org/10.7150/jca.34374.
Shahi Thakuri P, Gupta M, Singh S, et al. (2020). Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling. BMC Cancer 20:4. https://doi.org/10.1186/s12885-019-6479-2
Singh S, Sharma B, Kanwar SS, Kumar A (2016). Lead phytochemicals for anticancer drug development. Front Plant Sci. 8;7:1667. https://doi.org/10.3389/fpls.2016.01667
Sohel M, Aktar S, Biswas P, Amin MA, Hossain MA, Ahmed N, Mim MIH, Islam F, Mamun AA (2023). Exploring the anti-cancer potential of dietary phytochemicals for the patients with breast cancer: A comprehensive review. Cancer Med doi: 10.1002/cam4.5984. Epub ahead of print. PMID: 37132286.
Vladu AF, Ficai D, Ene AG, Ficai A (2022). Combination therapy using polyphenols: an efficient way to improve antitumoral activity and reduce resistance. Int J Mol Sci. 23(18):10244. https://doi.org/10.3390/ijms231810244
Zhou Y, Zheng J, Li Y, Xu DP, Li S, Chen YM, Li HB (2016). Natural polyphenols for prevention and treatment of cancer. Nutrients. 8(8):515.
https://doi.org/10.3390/nu8080515
Zunica ERM, Axelrod CL, Kirwan JP (2022). Phytochemical targeting of mitochondria for breast cancer chemoprevention, therapy, and sensitization. Int J Mol Sci 23(22):14152. https://doi.org/10.3390/ijms232214152
